Ontology highlight
ABSTRACT:
SUBMITTER: Albrecht DS
PROVIDER: S-EPMC5908728 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Pain 20180501 5
Numerous preclinical studies support the role of spinal neuroimmune activation in the pathogenesis of chronic pain, and targeting glia (eg, microglia/astrocyte)- or macrophage-mediated neuroinflammatory responses effectively prevents or reverses the establishment of persistent nocifensive behaviors in laboratory animals. However, thus far, the translation of those findings into novel treatments for clinical use has been hindered by the scarcity of data supporting the role of neuroinflammation in ...[more]