Unknown

Dataset Information

0

Acid-base status and its clinical implications in critically ill patients with cirrhosis, acute-on-chronic liver failure and without liver disease.


ABSTRACT: BACKGROUND:Acid-base disturbances are frequently observed in critically ill patients at the intensive care unit. To our knowledge, the acid-base profile of patients with acute-on-chronic liver failure (ACLF) has not been evaluated and compared to critically ill patients without acute or chronic liver disease. RESULTS:One hundred and seventy-eight critically ill patients with liver cirrhosis were compared to 178 matched controls in this post hoc analysis of prospectively collected data. Patients with and without liver cirrhosis showed hyperchloremic acidosis and coexisting hypoalbuminemic alkalosis. Cirrhotic patients, especially those with ACLF, showed a marked net metabolic acidosis owing to increased lactate and unmeasured anions. This metabolic acidosis was partly antagonized by associated respiratory alkalosis, yet with progression to ACLF resulted in acidemia, which was present in 62% of patients with ACLF grade III compared to 19% in cirrhosis patients without ACLF. Acidemia and metabolic acidosis were associated with 28-day mortality in cirrhosis. Patients with pH values

SUBMITTER: Drolz A 

PROVIDER: S-EPMC5908779 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature

altmetric image

Publications

Acid-base status and its clinical implications in critically ill patients with cirrhosis, acute-on-chronic liver failure and without liver disease.

Drolz Andreas A   Horvatits Thomas T   Roedl Kevin K   Rutter Karoline K   Brunner Richard R   Zauner Christian C   Schellongowski Peter P   Heinz Gottfried G   Funk Georg-Christian GC   Trauner Michael M   Schneeweiss Bruno B   Fuhrmann Valentin V  

Annals of intensive care 20180419 1


<h4>Background</h4>Acid-base disturbances are frequently observed in critically ill patients at the intensive care unit. To our knowledge, the acid-base profile of patients with acute-on-chronic liver failure (ACLF) has not been evaluated and compared to critically ill patients without acute or chronic liver disease.<h4>Results</h4>One hundred and seventy-eight critically ill patients with liver cirrhosis were compared to 178 matched controls in this post hoc analysis of prospectively collected  ...[more]

Similar Datasets

| S-EPMC7526342 | biostudies-literature
| S-EPMC6660055 | biostudies-literature
| S-EPMC4223545 | biostudies-other
| S-EPMC8509281 | biostudies-literature
| S-EPMC10954432 | biostudies-literature
| S-EPMC10497461 | biostudies-literature
| S-EPMC8421951 | biostudies-literature
| S-EPMC7652102 | biostudies-literature
| S-EPMC8039323 | biostudies-literature
| S-EPMC5483493 | biostudies-other