Ontology highlight
ABSTRACT:
SUBMITTER: Dal Maso E
PROVIDER: S-EPMC5908784 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Dal Maso Emma E Zhu Yue Y Pham Vi V Reynolds Christopher A CA Deganutti Giuseppe G Hick Caroline A CA Yang Dehua D Christopoulos Arthur A Hay Debbie L DL Wang Ming-Wei MW Sexton Patrick M PM Furness Sebastian G B SGB Wootten Denise D
Biochemical pharmacology 20180216
Class B peptide hormone GPCRs are targets for the treatment of major chronic disease. Peptide ligands of these receptors display biased agonism and this may provide future therapeutic advantage. Recent active structures of the calcitonin (CT) and glucagon-like peptide-1 (GLP-1) receptors reveal distinct engagement of peptides with extracellular loops (ECLs) 2 and 3, and mutagenesis of the GLP-1R has implicated these loops in dynamics of receptor activation. In the current study, we have mutated ...[more]