Ontology highlight
ABSTRACT:
SUBMITTER: Li Z
PROVIDER: S-EPMC5908793 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Li Zhaoyan Z Wang Yan Y Li Yadan Y Yin Wanqi W Mo Libin L Qian Xianghao X Zhang Yiran Y Wang Guifen G Bu Fan F Zhang Zhiling Z Ren Xiaofang X Zhu Baochang B Niu Chang C Xiao Wei W Zhang Weiwei W
Cell death & disease 20180501 5
The canonical Wnt/β-Catenin signaling pathway is widely involved in regulating diverse biological processes. Dysregulation of the pathway results in severe consequences, such as developmental defects and malignant cancers. Here, we identified Ube2s as a novel activator of the Wnt/β-Catenin signaling pathway. It modified β-Catenin at K19 via K11-linked polyubiquitin chain. This modification resulted in an antagonistic effect against the destruction complex/β-TrCP cascade-orchestrated β-Catenin de ...[more]