Ontology highlight
ABSTRACT:
SUBMITTER: Dufva O
PROVIDER: S-EPMC5908809 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Nature communications 20180419 1
Aggressive natural killer-cell (NK-cell) leukemia (ANKL) is an extremely aggressive malignancy with dismal prognosis and lack of targeted therapies. Here, we elucidate the molecular pathogenesis of ANKL using a combination of genomic and drug sensitivity profiling. We study 14 ANKL patients using whole-exome sequencing (WES) and identify mutations in STAT3 (21%) and RAS-MAPK pathway genes (21%) as well as in DDX3X (29%) and epigenetic modifiers (50%). Additional alterations include JAK-STAT copy ...[more]