Ontology highlight
ABSTRACT:
SUBMITTER: Montalvao F
PROVIDER: S-EPMC5909033 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Montalvão Fabricio F Nascimento Danielle Oliveira DO Nunes Marise P MP Koeller Carolina M CM Morrot Alexandre A Lery Leticia Miranda S LMS Bisch Paulo M PM Teixeira Santuza M R SMR Vasconcellos Rita R Freire-de-Lima Leonardo L Lopes Marcela F MF Heise Norton N DosReis George A GA Freire-de-Lima Célio Geraldo CG
Frontiers in immunology 20180413
Few studies investigate the major protein antigens targeted by the antibody diversity of infected mice with <i>Trypanosoma cruzi</i>. To detect global IgG antibody specificities, sera from infected mice were immunoblotted against whole <i>T. cruzi</i> extracts. By proteomic analysis, we were able to identify the most immunogenic <i>T. cruzi</i> proteins. We identified three major antigens as pyruvate phosphate dikinase, Hsp-85, and β-tubulin. The major protein band recognized by host IgG was <i> ...[more]