Ontology highlight
ABSTRACT:
SUBMITTER: Roithova A
PROVIDER: S-EPMC5909452 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Roithová Adriana A Klimešová Klára K Pánek Josef J Will Cindy L CL Lührmann Reinhard R Stanek David D Girard Cyrille C
Nucleic acids research 20180401 7
Cajal bodies (CBs) are nuclear non-membrane bound organelles where small nuclear ribonucleoprotein particles (snRNPs) undergo their final maturation and quality control before they are released to the nucleoplasm. However, the molecular mechanism how immature snRNPs are targeted and retained in CBs has yet to be described. Here, we microinjected and expressed various snRNA deletion mutants as well as chimeric 7SK, Alu or bacterial SRP non-coding RNAs and provide evidence that Sm and SMN binding ...[more]