Ontology highlight
ABSTRACT:
SUBMITTER: Lee HH
PROVIDER: S-EPMC5909599 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Lee Hyung Ho HH Kim Sook Young SY Na Joon Chae JC Yoon Young Eun YE Han Woong Kyu WK
PloS one 20180419 4
Pentraxin-3 (PTX3) is a long-form member of the pentraxin family of proteins that has been studied in inflammatory diseases and in various organs. We found that PTX3 protects kidney cells during ischemia and proinflammatory acute kidney injury. The aim of this study was to develop an in vitro experimental model of acute kidney injury and to analyze the protective mechanism of exogenous recombinant PTX3. In this study, cells of the HK-2 renal tubular cell line were treated with a calcium ionophor ...[more]