Dataset Information

Significant association of BDNF rs6265 G>A polymorphism with susceptibility to epilepsy: a meta-analysis.

ABSTRACT:

Introduction

Previously published articles have suggested that BDNF rs6265 G>A polymorphism is a potential risk factor for epilepsy. However, the results were not consistent.

Methods

We conducted a meta-analysis to explore the association between BDNF rs6265 G>A polymorphism and epilepsy risk. Four online databases were searched, and related studies were reviewed from their inception up to June 20, 2017. ORs and corresponding 95% CIs were used to calculate the associations of each genetic model. Overall, 10 case-control publications involving 9,512 subjects were included in this meta-analysis.

Results

Significant associations were found between BDNF rs6265 G>A polymorphism and epilepsy (A vs G: OR=0.88, 95% CI=0.83-0.94, P<0.01, I²=0%; GA vs GG: OR=0.88, 95% CI=0.79-0.97, P=0.01, I²=0%; AA vs GG: OR=0.79, 95% CI=0.70-0.90, P<0.01, I²=0%; GA+AA vs GG: OR=0.85, 95% CI=0.77-0.94, P<0.01, I²=0%; AA vs GG+GA: OR=0.85, 95% CI=0.76-0.95, P=0.01, I²=0%). Subgroup analysis also showed similar results in an Asian population.

Conclusion

Our meta-analysis indicated that BDNF rs6265 G>A polymorphism might be involved in epilepsy susceptibility, especially in the Asian population.

SUBMITTER: Xu YL

PROVIDER: S-EPMC5909779 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Publications

Significant association of <i>BDNF</i> rs6265 G>A polymorphism with susceptibility to epilepsy: a meta-analysis.

Xu Yue-Long YL Li Xiu-Xiu XX Zhuang Su-Jing SJ Guo Shi-Feng SF Xiang Jian-Ping JP Wang Long L Zhou Lan L Wu Bin B

Neuropsychiatric disease and treatment 20180416

<h4>Introduction</h4>Previously published articles have suggested that <i>BDNF</i> rs6265 G>A polymorphism is a potential risk factor for epilepsy. However, the results were not consistent.<h4>Methods</h4>We conducted a meta-analysis to explore the association between <i>BDNF</i> rs6265 G>A polymorphism and epilepsy risk. Four online databases were searched, and related studies were reviewed from their inception up to June 20, 2017. ORs and corresponding 95% CIs were used to calculate the associ ...[more]

PMID: 29713173

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Project description:BackgroundBrain-derived neurotrophic factor (BDNF), a neurotransmitter modulator, plays a significant role in neuronal survival and growth and participates in neuronal plasticity, thus being essential for learning, memory, and the development of cognition. Additionally, it is crucial for appetite, weight, and metabolic control and plays a pivotal role in the cardiovascular system. The Val66Met polymorphism (rs6265) of the BDNF gene causes a decrease in BDNF secretion and plays a role in impairments in cognition, energy homeostasis, and cardiovascular events. The present study aimed to evaluate the association of polymorphism (rs6265) of the BDNF gene with three quantitative traits simultaneously, namely, intelligence quotient (IQ), body mass index (BMI), and blood pressure (BP).MethodsPsychometric, morphometric, and physiometric data of the total participants (N = 246) were collected. WASI-IIINDIA was used to measure cognitive ability. Genotyping was carried out using allele-specific PCR for the rs6265 polymorphism (C196T), and genotypes were determined. Statistical analyses were performed at p < 0.05 significance level using MS-Excel and SigmaPlot. The odds ratio models with a 95% confidence interval were used to test the associations. The used models are co-dominant, recessive, dominant, over-dominant, and additive.ResultsThe allelic frequencies of alleles C and T were 72 and 28%, respectively. Under the dominant genetic model, a significant susceptible association of minor allele T was observed with a lower average verbal comprehensive index (OR = 2.216, p = 0.003, CI (95%) =1.33-3.69), a lower average performance reasoning index (OR = 2.634, p < 0.001, CI (95%) = 1.573-4.41), and a lower average full-scale IQ-4 (OR = 3.159, p < 0.001, CI (95%) = 1.873-5.328). Carriers of Met-alleles were found to have an increased body mass index (OR = 2.538, p < 0.001, CI (95%) = 1.507-4.275), decreased systolic blood pressure (OR = 2.051, p = 0.012, CI (95%) = 1.202-3.502), and decreased diastolic blood pressure (OR = 2.162, p = 0.006, CI (95%) = 1.278-3.657). Under the recessive genetic model, several folds decrease in IQ and BP and an increase in BMI with the presence of the T allele was also detected.ConclusionThis novel study may improve our understanding of genetic alterations to the traits and hence be helpful for clinicians and researchers to investigate the diagnostic and prognostic value of this neurotrophic factor.