Significant association of BDNF rs6265 G>A polymorphism with susceptibility to epilepsy: a meta-analysis.

ABSTRACT:

Introduction

Previously published articles have suggested that BDNF rs6265 G>A polymorphism is a potential risk factor for epilepsy. However, the results were not consistent.

Methods

We conducted a meta-analysis to explore the association between BDNF rs6265 G>A polymorphism and epilepsy risk. Four online databases were searched, and related studies were reviewed from their inception up to June 20, 2017. ORs and corresponding 95% CIs were used to calculate the associations of each genetic model. Overall, 10 case-control publications involving 9,512 subjects were included in this meta-analysis.

Results

Significant associations were found between BDNF rs6265 G>A polymorphism and epilepsy (A vs G: OR=0.88, 95% CI=0.83-0.94, P<0.01, I²

SUBMITTER: Xu YL 

PROVIDER: S-EPMC5909779 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature