Ontology highlight
ABSTRACT:
SUBMITTER: Lutz TA
PROVIDER: S-EPMC5910000 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Lutz Thomas A TA Coester Bernd B Whiting Lynda L Dunn-Meynell Ambrose A AA Boyle Christina N CN Bouret Sebastien G SG Levin Barry E BE Le Foll Christelle C
Diabetes 20180221 5
Amylin phosphorylates ERK (p-ERK) in the area postrema to reduce eating and synergizes with leptin to phosphorylate STAT3 in the arcuate (ARC) and ventromedial (VMN) hypothalamic nuclei to reduce food intake and body weight. The current studies assessed potential amylin and amylin-leptin ARC/VMN interactions on ERK signaling and their roles in postnatal hypothalamic pathway development. In amylin knockout mice, the density of agouti-related protein (AgRP)-immunoreactive (IR) fibers in the hypoth ...[more]