Prenatal Development and Adolescent Obesity: Two Distinct Pathways to Diabetes in Adulthood.

ABSTRACT: OBJECTIVE:Higher body-mass index (BMI) and lower birth weight (BW) are associated with elevated risk of diabetes in adulthood, but the extent to which they compose two distinct pathways is unclear. METHODS:We used data from the National Longitudinal Study of Adolescent to Adult Health, a cohort of adolescents (1994-1995) followed for 14 years over four waves into adulthood (n = 13,413). Sex-stratified path analysis was used to examine pathways from BW [kg; linear (BW) and quadratic (BW2)] to latent trajectories in BMI from adolescence to adulthood to prevalent diabetes or prediabetes (pre/diabetes) in adulthood, adjusting for sociodemographic characteristics. RESULTS:Two pathways from BW to pre/diabetes were characterized: one from higher BW to elevated BMI and pre/diabetes and a second fr

SUBMITTER: Boone-Heinonen J 

PROVIDER: S-EPMC5910034 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature