Ontology highlight
ABSTRACT:
SUBMITTER: James CA
PROVIDER: S-EPMC5910231 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Cell chemical biology 20180201 4
Mycobacterial cell wall lipids bind the conserved CD1 family of antigen-presenting molecules and activate T cells via their T cell receptors (TCRs). Sulfoglycolipids (SGLs) are uniquely synthesized by Mycobacterium tuberculosis, but tools to study SGL-specific T cells in humans are lacking. We designed a novel hybrid synthesis of a naturally occurring SGL, generated CD1b tetramers loaded with natural or synthetic SGL analogs, and studied the molecular requirements for TCR binding and T cell acti ...[more]