Ontology highlight
ABSTRACT:
SUBMITTER: Labib M
PROVIDER: S-EPMC5910253 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Labib Mahmoud M Mohamadi Reza M RM Poudineh Mahla M Ahmed Sharif U SU Ivanov Ivaylo I Huang Ching-Lung CL Moosavi Maral M Sargent Edward H EH Kelley Shana O SO
Nature chemistry 20180402 5
Cell-to-cell variation in gene expression creates a need for techniques that can characterize expression at the level of individual cells. This is particularly true for rare circulating tumour cells, in which subtyping and drug resistance are of intense interest. Here we describe a method for cell analysis-single-cell mRNA cytometry-that enables the isolation of rare cells from whole blood as a function of target mRNA sequences. This approach uses two classes of magnetic particles that are label ...[more]