Ontology highlight
ABSTRACT:
SUBMITTER: Bzymek KP
PROVIDER: S-EPMC5910394 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Bzymek Krzysztof P KP Puckett James W JW Zer Cindy C Xie Jun J Ma Yuelong Y King Jeremy D JD Goodstein Leah H LH Avery Kendra N KN Colcher David D Singh Gagandeep G Horne David A DA Williams John C JC
Nature communications 20180420 1
Because monoclonal antibodies (mAbs) have exceptional specificity and favorable pharmacology, substantial efforts have been made to functionalize them, either with potent cytotoxins, biologics, radionuclides, or fluorescent groups for therapeutic benefit and/or use as theranostic agents. To exploit our recently discovered meditope-Fab interaction as an alternative means to efficiently functionalize mAbs, we used insights from the structure to enhance the affinity and lifetime of the interaction ...[more]