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Individual and shared effects of social environment and polygenic risk scores on adolescent body mass index.


ABSTRACT: Juvenile obesity is associated with adverse health outcomes. Understanding genetic and environmental influences on body mass index (BMI) during adolescence could inform interventions. We investigated independent and interactive effects of parenting, socioeconomic status (SES) and polygenic risk on BMI pre-adolescence, and on the rate of change in BMI across adolescence. Genome-wide genotype data, BMI and child perceptions of parental warmth and punitive discipline were available at 11 years old, and parental SES was available from birth on 3,414 unrelated participants. Linear models were used to test the effects of social environment and polygenic risk on pre-adolescent BMI. Change in BMI across adolescence was assessed in a subset (N?=?1943). Sex-specific effects were assessed. Higher genetic risk was associated with increased BMI pre-adolescence and across adolescence (p?

SUBMITTER: Coleman JRI 

PROVIDER: S-EPMC5910407 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature

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Individual and shared effects of social environment and polygenic risk scores on adolescent body mass index.

Coleman Jonathan R I JRI   Krapohl Eva E   Eley Thalia C TC   Breen Gerome G  

Scientific reports 20180420 1


Juvenile obesity is associated with adverse health outcomes. Understanding genetic and environmental influences on body mass index (BMI) during adolescence could inform interventions. We investigated independent and interactive effects of parenting, socioeconomic status (SES) and polygenic risk on BMI pre-adolescence, and on the rate of change in BMI across adolescence. Genome-wide genotype data, BMI and child perceptions of parental warmth and punitive discipline were available at 11 years old,  ...[more]

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