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The role of retinoic acid signaling in starfish metamorphosis.


ABSTRACT: Background:Although retinoic acid (RA) signaling plays a crucial role in the body patterning of chordates, its function in non-chordate invertebrates, other than its mediation of environmental cues triggering metamorphosis in cnidarians, is largely unknown. We investigated the role of RA signaling in the metamorphosis of starfish (Echinodermata). Results:We found that exogenous RA treatment induced metamorphosis in starfish larvae. In contrast, inhibitors of RA synthesis and RA receptors suppressed metamorphosis triggered by attachment to a substrate. Gene expressions of the RA signaling component were detected in competent larvae. Conclusions:This study provides insight into the ancestral function of RA signaling, which is conserved in the metamorphosis of cnidarians and starfish.

SUBMITTER: Yamakawa S 

PROVIDER: S-EPMC5910596 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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The role of retinoic acid signaling in starfish metamorphosis.

Yamakawa Shumpei S   Morino Yoshiaki Y   Honda Masanao M   Wada Hiroshi H  

EvoDevo 20180421


<h4>Background</h4>Although retinoic acid (RA) signaling plays a crucial role in the body patterning of chordates, its function in non-chordate invertebrates, other than its mediation of environmental cues triggering metamorphosis in cnidarians, is largely unknown. We investigated the role of RA signaling in the metamorphosis of starfish (Echinodermata).<h4>Results</h4>We found that exogenous RA treatment induced metamorphosis in starfish larvae. In contrast, inhibitors of RA synthesis and RA re  ...[more]

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