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The role of retinoic acid signaling in starfish metamorphosis.
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ABSTRACT: Background
Although retinoic acid (RA) signaling plays a crucial role in the body patterning of chordates, its function in non-chordate invertebrates, other than its mediation of environmental cues triggering metamorphosis in cnidarians, is largely unknown. We investigated the role of RA signaling in the metamorphosis of starfish (Echinodermata).Results
We found that exogenous RA treatment induced metamorphosis in starfish larvae. In contrast, inhibitors of RA synthesis and RA receptors suppressed metamorphosis triggered by attachment to a substrate. Gene expressions of the RA signaling component were detected in competent larvae.Conclusions
This study provides insight into the ancestral function of RA signaling, which is conserved in the metamorphosis of cnidarians and starfish.
SUBMITTER: Yamakawa S
PROVIDER: S-EPMC5910596 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Publications
The role of retinoic acid signaling in starfish metamorphosis.
EvoDevo 20180421
<h4>Background</h4>Although retinoic acid (RA) signaling plays a crucial role in the body patterning of chordates, its function in non-chordate invertebrates, other than its mediation of environmental cues triggering metamorphosis in cnidarians, is largely unknown. We investigated the role of RA signaling in the metamorphosis of starfish (Echinodermata).<h4>Results</h4>We found that exogenous RA treatment induced metamorphosis in starfish larvae. In contrast, inhibitors of RA synthesis and RA re ...[more]