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Pediatric norovirus GII.4 infections in Nicaragua, 1999-2015.


ABSTRACT: OBJECTIVES:Investigate clinical and epidemiological factors of pediatric GII.4 norovirus infections in children with acute gastroenteritis (AGE) in Nicaragua between 1999 and 2015. METHODS:We retrospectively analyzed laboratory and epidemiologic data from 1,790 children?7years with AGE from 6 hospitals in Nicaragua (n=538), and 3 community clinics (n=919) and households (n=333) in León, between 1999 and 2015. Moreover, asymptomatic children from community clinics (n=162) and households (n=105) were enrolled. Norovirus was detected by real-time PCR and genotyped by sequencing the N-terminal and shell region of the capsid gene. RESULTS:Norovirus was found in 19% (n=338) and 12% (n=32) of children with and without AGE, respectively. In total, 20 genotypes including a tentatively new genotype were detected. Among children with AGE, the most common genotypes were GII.4 (53%), GII.14 (7%), GII.3 (6%) and GI.3 (6%). In contrast, only one (1.4%) GII.4 was found in asymptomatic children. The prevalence of GII.4 infections was significantly higher in children between 7 and 12months of age. The prevalence of GII.4 was lowest in households (38%), followed by community clinics (50%) and hospitals (75%). Several different GII.4 variants were detected and their emergence followed the global temporal trend. CONCLUSIONS:Overall our study found the predominance of pediatric GII.4 norovirus infections in Nicaragua mostly occurring in children between 7 and 12months of age, implicating GII.4 as the main norovirus vaccine target.

SUBMITTER: Bucardo F 

PROVIDER: S-EPMC5911913 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature

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Pediatric norovirus GII.4 infections in Nicaragua, 1999-2015.

Bucardo Filemón F   Reyes Yaoska Y   Becker-Dreps Sylvia S   Bowman Natalie N   Gruber Joann F JF   Vinjé Jan J   Espinoza Felix F   Paniagua Margarita M   Balmaseda Angel A   Svensson Lennart L   Nordgren Johan J  

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 20171002


<h4>Objectives</h4>Investigate clinical and epidemiological factors of pediatric GII.4 norovirus infections in children with acute gastroenteritis (AGE) in Nicaragua between 1999 and 2015.<h4>Methods</h4>We retrospectively analyzed laboratory and epidemiologic data from 1,790 children≤7years with AGE from 6 hospitals in Nicaragua (n=538), and 3 community clinics (n=919) and households (n=333) in León, between 1999 and 2015. Moreover, asymptomatic children from community clinics (n=162) and house  ...[more]

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