Ontology highlight
ABSTRACT:
SUBMITTER: Flores-Langarica A
PROVIDER: S-EPMC5912514 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Mucosal immunology 20171220 3
Antibody responses induced at mucosal and nonmucosal sites demonstrate a significant level of autonomy. Here, we demonstrate a key role for mucosal interferon regulatory factor-4 (IRF4)-dependent CD103<sup>+</sup>CD11b<sup>+</sup> (DP), classical dendritic cells (cDCs) in the induction of T-dependent immunoglobulin G (IgG) and immunoglobulin A (IgA) responses in the mesenteric lymph node (MLN) following systemic immunization with soluble flagellin (sFliC). In contrast, IRF8-dependent CD103<sup>+ ...[more]