Ontology highlight
ABSTRACT:
SUBMITTER: Lange M
PROVIDER: S-EPMC5912797 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Lange Merlin M Froc Cynthia C Grunwald Hannah H Norton William H J WHJ Bally-Cuif Laure L
Progress in neuro-psychopharmacology & biological psychiatry 20180226 Pt A
Polymorphisms in the gene coding for the adhesion G-protein coupled receptor LPHN3 are a risk factor for attention-deficit/hyperactivity disorder (ADHD). Transient down-regulation of latrophilin3.1 (lphn3.1), the zebrafish LPHN3 homologue, causes hyperactivity. Zebrafish injected with a lphn3.1-specific morpholino are hyperactive and display an impairment in dopaminergic neuron development. In the present study we used lphn3.1 morphants to further characterize the changes to dopaminergic signali ...[more]