Ontology highlight
ABSTRACT:
SUBMITTER: Herz DM
PROVIDER: S-EPMC5912902 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Herz Damian M DM Little Simon S Pedrosa David J DJ Tinkhauser Gerd G Cheeran Binith B Foltynie Tom T Bogacz Rafal R Brown Peter P
Current biology : CB 20180329 8
To optimally balance opposing demands of speed and accuracy during decision-making, we must flexibly adapt how much evidence we require before making a choice. Such adjustments in decision thresholds have been linked to the subthalamic nucleus (STN), and therapeutic STN deep-brain stimulation (DBS) has been shown to interfere with this function. Here, we performed continuous as well as closed-loop DBS of the STN while Parkinson's disease patients performed a perceptual decision-making task. Clos ...[more]