Ontology highlight
ABSTRACT:
SUBMITTER: Sherlock ME
PROVIDER: S-EPMC5912903 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Sherlock Madeline E ME Sudarsan Narasimhan N Stav Shira S Breaker Ronald R RR
eLife 20180305
Gene control systems sometimes interpret multiple signals to set the expression levels of the genes they regulate. In rare instances, ligand-binding riboswitch aptamers form tandem arrangements to approximate the function of specific two-input Boolean logic gates. Here, we report the discovery of riboswitch aptamers for phosphoribosyl pyrophosphate (PRPP) that naturally exist either in singlet arrangements, or occur in tandem with guanine aptamers. Tandem guanine-PRPP aptamers can bind the targe ...[more]