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RNA-Dependent Intergenerational Inheritance of Enhanced Synaptic Plasticity after Environmental Enrichment.

ABSTRACT: Physical exercise in combination with cognitive training is known to enhance synaptic plasticity, learning, and memory and lower the risk for various complex diseases including Alzheimer's disease. Here, we show that exposure of adult male mice to an environmental enrichment paradigm leads to enhancement of synaptic plasticity and cognition also in the next generation. We show that this effect is mediated through sperm RNA and especially miRs 212/132. In conclusion, our study reports intergenerational inheritance of an acquired cognitive benefit and points to specific miRs as candidates mechanistically involved in this type of transmission.

SUBMITTER: Benito E

PROVIDER: S-EPMC5912949 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature

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RNA-Dependent Intergenerational Inheritance of Enhanced Synaptic Plasticity after Environmental Enrichment.

Benito Eva E Kerimoglu Cemil C Ramachandran Binu B Pena-Centeno Tonatiuh T Jain Gaurav G Stilling Roman Manuel RM Islam Md Rezaul MR Capece Vincenzo V Zhou Qihui Q Edbauer Dieter D Dean Camin C Fischer André A

Cell reports 20180401 2

Physical exercise in combination with cognitive training is known to enhance synaptic plasticity, learning, and memory and lower the risk for various complex diseases including Alzheimer's disease. Here, we show that exposure of adult male mice to an environmental enrichment paradigm leads to enhancement of synaptic plasticity and cognition also in the next generation. We show that this effect is mediated through sperm RNA and especially miRs 212/132. In conclusion, our study reports intergenera ...[more]

PMID: 29642011

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