Ontology highlight
ABSTRACT:
SUBMITTER: Feltham R
PROVIDER: S-EPMC5912950 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Feltham Rebecca R Jamal Kunzah K Tenev Tencho T Liccardi Gianmaria G Jaco Isabel I Domingues Celia Monteiro CM Morris Otto O John Sidonie Wicky SW Annibaldi Alessandro A Widya Marcella M Kearney Conor J CJ Clancy Danielle D Elliott Paul R PR Glatter Timo T Qiao Qi Q Thompson Andrew J AJ Nesvizhskii Alexey A Schmidt Alexander A Komander David D Wu Hao H Martin Seamus S Meier Pascal P
Cell reports 20180401 2
Tumor necrosis factor (TNF) is an inflammatory cytokine that can signal cell survival or cell death. The mechanisms that switch between these distinct outcomes remain poorly defined. Here, we show that the E3 ubiquitin ligase Mind Bomb-2 (MIB2) regulates TNF-induced cell death by inactivating RIPK1 via inhibitory ubiquitylation. Although depletion of MIB2 has little effect on NF-κB activation, it sensitizes cells to RIPK1- and caspase-8-dependent cell death. We find that MIB2 represses the cytot ...[more]