Unknown

Dataset Information

0

Novel Plasma Proteins in Nepalese School-aged Children are Associated with a Small Head Size at Birth.


ABSTRACT: Fetal growth restriction increases the risk of poor childhood growth and development and chronic disease in adulthood. Yet, little is known about biological pathways that mediate the long-lasting effects of suboptimal intrauterine growth. We explored the plasma proteome in a cohort of 500 Nepalese children 6-8 years of age to identify plasma proteins associated with multiple anthropometric size indicators at birth. Among 982 proteins analyzed, no proteins differed by birth weight, length, or weight-for-length indicators. However, 25 proteins were differentially abundant in children with a small vs normal head circumference at birth (<-2 vs. ?-2 z-scores of the WHO growth standards). Angiopoietin-like 6 was 19.4% more abundant and the other 24 proteins were 7-21% less abundant in children with a small vs normal head circumference at birth, adjusted for potential confounders. The less abundant proteins included actins, actin filament organizing proteins (?-actinin, talin, filamin, cofilin, profilin, and vinculin), proteins involved in muscle contraction, and glycolytic enzymes, which were all positively correlated with each other. A novel cluster of childhood plasma proteins involved in angiogenesis and cytoskeleton dynamics was associated with a small head size at birth. The prognostic value of an altered proteomic phenotype remains to be investigated.

SUBMITTER: Lee SE 

PROVIDER: S-EPMC5913316 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature

altmetric image

Publications

Novel Plasma Proteins in Nepalese School-aged Children are Associated with a Small Head Size at Birth.

Lee Sun Eun SE   West Keith P KP   Cole Robert N RN   Schulze Kerry J KJ   Wu Lee S-F LS   Yager James D JD   Groopman John J   Christian Parul P  

Scientific reports 20180423 1


Fetal growth restriction increases the risk of poor childhood growth and development and chronic disease in adulthood. Yet, little is known about biological pathways that mediate the long-lasting effects of suboptimal intrauterine growth. We explored the plasma proteome in a cohort of 500 Nepalese children 6-8 years of age to identify plasma proteins associated with multiple anthropometric size indicators at birth. Among 982 proteins analyzed, no proteins differed by birth weight, length, or wei  ...[more]

Similar Datasets

| S-EPMC5937903 | biostudies-literature
| S-EPMC5320403 | biostudies-literature
| S-EPMC4319538 | biostudies-other
| S-EPMC4670104 | biostudies-literature
| S-EPMC6879017 | biostudies-literature
| S-EPMC5314728 | biostudies-literature
| S-EPMC6646907 | biostudies-literature
| S-EPMC6619677 | biostudies-literature
2009-09-30 | GSE17390 | GEO
2010-05-22 | E-GEOD-17390 | biostudies-arrayexpress