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Treatment patterns and low-density lipoprotein cholesterol (LDL-C) goal attainment among patients receiving high- or moderate-intensity statins.


ABSTRACT: European clinical guidelines recommend a low-density lipoprotein cholesterol (LDL-C) goal of ?2 million individuals annually) to identify ASCVD (coronary atherosclerosis, stable/unstable angina, myocardial infarction, ischemic stroke, transient ischemic attack, aneurysm, peripheral artery disease) patients on moderate-/high-intensity statin in Germany. Proportion of patients with LDL-C??14,000 patients assessed in each year (mean age 71 years, 35% female, 8-12% taking high-intensity statins), approximately 80% had LDL-C???70 mg/dL. Treatment patterns were assessed for most (88-93%) patients. Approximately 79-81% of patients made no change to statin regimens, 1% switched statins, 14-16% discontinued; 1% of moderate-intensity patients up-titrated, and 3% of all patients down-titrated. LDL-C goal attainment in these treatment pattern groups was 20, 16-24, 17, 11-14, and 17-19%, respectively.Majority of ASCVD patients had LDL-C???70 mg/dL while on moderate-/high-intensity statins. Despite low LDL-C goal attainment, few patients changed their treatment regimens.

SUBMITTER: Fox KM 

PROVIDER: S-EPMC5913378 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature

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Treatment patterns and low-density lipoprotein cholesterol (LDL-C) goal attainment among patients receiving high- or moderate-intensity statins.

Fox Kathleen M KM   Tai Ming-Hui MH   Kostev Karel K   Hatz Maximilian M   Qian Yi Y   Laufs Ulrich U  

Clinical research in cardiology : official journal of the German Cardiac Society 20171222 5


<h4>Background</h4>European clinical guidelines recommend a low-density lipoprotein cholesterol (LDL-C) goal of < 70 mg/dL. Statin use varies and past studies suggest low rates of real-world goal attainment. This study describes LDL-C goal attainment among atherosclerotic CV disease (ASCVD) patients with various utilization patterns of moderate- or high-intensity statins in routine care.<h4>Methods</h4>This retrospective cohort study used electronic medical records data from the QuintilesIMS® Di  ...[more]

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