Dataset Information

Racial/ethnic differences in the epidemiology of ovarian cancer: a pooled analysis of 12 case-control studies.

ABSTRACT: Background:Ovarian cancer incidence differs substantially by race/ethnicity, but the reasons for this are not well understood. Data were pooled from the African American Cancer Epidemiology Study (AACES) and 11 case-control studies in the Ovarian Cancer Association Consortium (OCAC) to examine racial/ethnic differences in epidemiological characteristics with suspected involvement in epithelial ovarian cancer (EOC) aetiology. Methods:We used multivariable logistic regression to estimate associations for 17 reproductive, hormonal and lifestyle characteristics and EOC risk by race/ethnicity among 10 924 women with invasive EOC (8918 Non-Hispanic Whites, 433 Hispanics, 911 Blacks, 662 Asian/Pacific Islanders) and 16 150 controls (13 619 Non-Hispanic Whites, 533 Hispanics, 1233 Blacks, 765 Asian/Pacific Islanders). Likelihood ratio tests were used to evaluate heterogeneity in the risk factor associations by race/ethnicity. Results:We observed statistically significant racial/ethnic heterogeneity for hysterectomy and EOC risk (P?=?0.008), where the largest odds ratio (OR) was observed in Black women [OR?=?1.64, 95% confidence interval (CI)?=?1.34-2.02] compared with other racial/ethnic groups. Although not statistically significant, the associations for parity, first-degree family history of ovarian or breast cancer, and endometriosis varied by race/ethnicity. Asian/Pacific Islanders had the greatest magnitude of association for parity (?3 births: OR?=?0.38, 95% CI?=?0.28-0.54), and Black women had the largest ORs for family history (OR?=?1.77, 95% CI?=?1.42-2.21) and endometriosis (OR?=?2.42, 95% CI?=?1.65-3.55). Conclusions:Although racial/ethnic heterogeneity was observed for hysterectomy, our findings support the validity of EOC risk factors across all racial/ethnic groups, and further suggest that any racial/ethnic population with a higher prevalence of a modifiable risk factor should be targeted to disseminate information about prevention.

SUBMITTER: Peres LC

PROVIDER: S-EPMC5913601 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature

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Racial/ethnic differences in the epidemiology of ovarian cancer: a pooled analysis of 12 case-control studies.

Peres Lauren C LC Risch Harvey H Terry Kathryn L KL Webb Penelope M PM Goodman Marc T MT Wu Anna H AH Alberg Anthony J AJ Bandera Elisa V EV Barnholtz-Sloan Jill J Bondy Melissa L ML Cote Michele L ML Funkhouser Ellen E Moorman Patricia G PG Peters Edward S ES Schwartz Ann G AG Terry Paul D PD Manichaikul Ani A Abbott Sarah E SE Camacho Fabian F Jordan Susan J SJ Nagle Christina M CM Rossing Mary Anne MA Doherty Jennifer A JA Modugno Francesmary F Moysich Kirsten K Ness Roberta R Berchuck Andrew A Cook Linda L Le Nhu N Brooks-Wilson Angela A Sieh Weiva W Whittemore Alice A McGuire Valerie V Rothstein Joseph J Anton-Culver Hoda H Ziogas Argyrios A Pearce Celeste L CL Tseng Chiuchen C Pike Malcom M Schildkraut Joellen M JM

International journal of epidemiology 20180401 2

<h4>Background</h4>Ovarian cancer incidence differs substantially by race/ethnicity, but the reasons for this are not well understood. Data were pooled from the African American Cancer Epidemiology Study (AACES) and 11 case-control studies in the Ovarian Cancer Association Consortium (OCAC) to examine racial/ethnic differences in epidemiological characteristics with suspected involvement in epithelial ovarian cancer (EOC) aetiology.<h4>Methods</h4>We used multivariable logistic regression to est ...[more]

PMID: 29211900

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Project description:ImportanceProstate cancer (PC) care has evolved rapidly as a result of changes in prostate-specific antigen testing, novel imaging, and newer treatments. The impact of these changes on PC epidemiology and racial disparities across disease states remains underexplored.ObjectiveTo characterize racial and ethnic differences in the epidemiology of PC states, including nonmetastatic hormone-sensitive PC (nmHSPC), metastatic HSPC (mHSPC), nonmetastatic castration-resistant PC (nmCRPC), and metastatic CRPC (mCRPC).Design, setting, and participantsThis is a retrospective, population-based cohort study of male US veterans aged 40 years and older with known race and ethnicity and no non-PC malignant neoplasm before study entry receiving care through the Veterans Health Administration. The study period was from 2012 to 2020, with follow-up through 2021. To identify active users, data capture included visits 18 months before and after the study period. Data analysis was performed from March to August 2023.ExposureSelf-identified race and ethnicity, classified as Black, White, or Hispanic.Main outcomes and measuresThe primary outcomes were annual age-adjusted incidence rates (IRs) and point prevalence for PC states by race and ethnicity. Trends were evaluated using joinpoint regression. Time to disease progression or death was estimated using nonparametric cumulative incidence. Competing risk models adjusted for age assessed the association of race and ethnicity on disease progression.ResultsThe study included 6 539 001 veterans (median [IQR] age, 65 [56-74] years), of whom 476 227 had PC (median [IQR] age, 69 [63-75] years). IRs varied by time frame and disease state. Across all states and years, the relative risk among Black vs White patients ranged from 2.09 (95% CI, 2.01-2.18; P < .001) for nmHSPC in 2012 to 4.12 (95% CI, 3.39-5.02; P < .001) for nmCRPC in 2017. In nmHSPC, hazard ratios for progression to mHSPC and nmCRPC were 1.36 (95% CI, 1.33-1.40) and 1.60 (95% CI, 1.51-1.70), respectively, for Black patients and 1.38 (95% CI, 1.31-1.45) and 1.55 (95% CI, 1.40-1.72), respectively, for Hispanic patients vs White patients. In contrast, in mCRPC, the hazard ratio for death was lower for Black (0.84; 95% CI, 0.81-0.88) and Hispanic (0.76; 95% CI, 0.69-0.83) patients compared with White patients.Conclusions and relevanceThis cohort study of veterans found that Black patients had more than 2-fold higher incidence of all disease states vs White patients. Progression risk was higher for Black and Hispanic patients in early-stage disease, but lower in later disease stages. Despite equal access, Black patients disproportionately experience PC, although progression risks relative to White patients differed according to disease state.

Dataset Information

Racial/ethnic differences in the epidemiology of ovarian cancer: a pooled analysis of 12 case-control studies.

Publications

Racial/ethnic differences in the epidemiology of ovarian cancer: a pooled analysis of 12 case-control studies.

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