Genetic Basis of Emerging Vancomycin, Linezolid, and Daptomycin Heteroresistance in a Case of Persistent Enterococcus faecium Bacteremia.
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ABSTRACT:
SUBMITTER: Chacko KI
PROVIDER: S-EPMC5913925 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Publications
Genetic Basis of Emerging Vancomycin, Linezolid, and Daptomycin Heteroresistance in a Case of Persistent Enterococcus faecium Bacteremia.
Chacko Kieran I KI Sullivan Mitchell J MJ Beckford Colleen C Altman Deena R DR Ciferri Brianne B Pak Theodore R TR Sebra Robert R Kasarskis Andrew A Hamula Camille L CL van Bakel Harm H
Antimicrobial agents and chemotherapy 20180327 4
Whole-genome sequencing was used to examine a persistent <i>Enterococcus faecium</i> bacteremia that acquired heteroresistance to three antibiotics in response to prolonged multidrug therapy. A comparison of the complete genomes before and after each change revealed the emergence of known resistance determinants for vancomycin and linezolid and suggested that a novel mutation in <i>fabF</i>, encoding a fatty acid synthase, was responsible for daptomycin nonsusceptibility. Plasmid recombination c ...[more]
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