Mass and charge distributions of amyloid fibers involved in neurodegenerative diseases: mapping heterogeneity and polymorphism.
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ABSTRACT:
SUBMITTER: Pansieri J
PROVIDER: S-EPMC5914292 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Publications
Mass and charge distributions of amyloid fibers involved in neurodegenerative diseases: mapping heterogeneity and polymorphism.
Pansieri Jonathan J Halim Mohammad A MA Vendrely Charlotte C Dumoulin Mireille M Legrand François F Sallanon Marcelle Moulin MM Chierici Sabine S Denti Simona S Dagany Xavier X Dugourd Philippe P Marquette Christel C Antoine Rodolphe R Forge Vincent V
Chemical science 20180205 10
Heterogeneity and polymorphism are generic features of amyloid fibers with some important effects on the related disease development. We report here the characterization, by charge detection mass spectrometry, of amyloid fibers made of three polypeptides involved in neurodegenerative diseases: Aβ<sub>1-42</sub> peptide, tau and α-synuclein. Beside the mass of individual fibers, this technique enables to characterize the heterogeneity and the polymorphism of the population. In the case of Aβ<sub> ...[more]
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