Dataset Information

The potential impact of sleep-related movement disorders on stroke risk: a population-based longitudinal study.

ABSTRACT:

Background

Sleep-related movement disorders (SRMD) have been shown to increase the risk of cardiovascular diseases. However, the relationship between SRMD and stroke remains unclear.

Aim

To explore the relationship between SRMD and stroke in the general population.

Design

Two cohorts of patients with SRMD and without SRMD were followed up for the occurrence of hemorrhagic and ischemic stroke.

Methods

The study cohort enrolled 604 patients who were initially diagnosed as SRMD between 2000 and 2005. 2,416 age- and sex-matched patients without prior stroke were selected as the comparison cohort. A Cox-proportional hazard regression analysis was performed for multivariate adjustment.

Results

Patients with SRMD had a higher risk for developing all-cause stroke [adjusted hazard ratio (HR)?=?2.29, 95% confidence interval (CI)?=?1.42-3.80]. Patients of below 45?years old had the greatest stroke risk (HR?=?4.03, 95% CI?=?3.11-5.62), followed by patients aged??65?years (HR?=?2.64, 95% CI?=?1.12-3.44) and 45-64?years (HR?=?1.07, 95% CI?=?1.02-1.71). The age-stratified analysis suggested that the increased risk of hemorrhagic stroke was more significant than ischemic stroke among all age groups. Furthermore, males with SRMD were at greater risk to develop all-cause stroke (HR?=?2.98, 95% CI?=?1.74-4.50) than that of females (HR?=?1.94, 95% CI?=?1.01-3.77).

Conclusions

Patients with SRMD were found to have an increased risk of all-cause stroke along with a higher possibility of hemorrhagic stroke over ischemic stroke.

SUBMITTER: Chou CH

PROVIDER: S-EPMC5914305 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature

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Publications

The potential impact of sleep-related movement disorders on stroke risk: a population-based longitudinal study.

Chou C-H CH Yin J-H JH Chen S-Y SY Lin C-C CC Sung Y-F YF Chung C-H CH Chien W-C WC Tsai C-K CK Tsai C-L CL Lin G-Y GY Lin Y-K YK Lee J-T JT

QJM : monthly journal of the Association of Physicians 20171001 10

<h4>Background</h4>Sleep-related movement disorders (SRMD) have been shown to increase the risk of cardiovascular diseases. However, the relationship between SRMD and stroke remains unclear.<h4>Aim</h4>To explore the relationship between SRMD and stroke in the general population.<h4>Design</h4>Two cohorts of patients with SRMD and without SRMD were followed up for the occurrence of hemorrhagic and ischemic stroke.<h4>Methods</h4>The study cohort enrolled 604 patients who were initially diagnosed ...[more]

PMID: 28482057

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Project description:Studies have shown a higher risk of depressive disorders in children with sleep apnea than in those without sleep apnea. However, the association between sleep apnea and subsequent depressive disorders in the pediatric population remains undetermined. Thus, this study investigated the risk of depressive disorders among pediatric patients with sleep apnea.In this study, the population-based National Health Insurance Research Database of Taiwan was used to identify patients who had first been diagnosed with sleep apnea between 1999 and 2013. Patients with sleep apnea who were younger than 18 years were included in the sleep apnea group. Controls (those without sleep apnea) were matched to patients with sleep apnea at a 1:10 ratio by age, sex, and index year. Patients who had baseline or inherited depressive disorders before the enrollment date were excluded. The two groups were followed up until December 31, 2013. The primary endpoint was the occurrence of one or more depressive disorders.At the end of this study, 6,237 children had been enrolled, comprising 567 children with sleep apnea and 5,670 children without sleep apnea. During the mean follow-up period of 5.87 years, a total of 77 children (1.23%) developed one or more depressive disorders; 14 (2.46%) from the sleep apnea group and 63 (1.11%) from the control group. Kaplan-Meier analysis showed that children with sleep apnea had a significantly higher risk of depressive disorders (log-rank test, p = 0.002). After adjusting for covariates, the risk of subsequent depressive disorders among children with sleep apnea was still significantly higher (hazard ratio [HR] = 2.25; 95% confidence interval [CI] = 1.25-4.05; p = 0.006). Moreover, boys with sleep apnea had a significantly higher risk than those without sleep apnea (adjusted HR = 3.77; 95% CI, 1.82-7.54; p < 0.001). Furthermore, in sleep apnea group, children older than 12 years of age had more risk to depression (hazard ratio (HR) = 7.1833, 95% confidence interval (CI), 2.3734 to 21.7411; p = 0.0004).This study found a significantly higher subsequent risk of depressive disorders in children with sleep apnea, particularly boys and those older than 12 years of age. The study findings strongly suggest that clinicians should provide psychological evaluation and supportive care for children with sleep apnea, in addition to medical treatment.

Project description:Background and purposeData for a relationship between salt intake and stroke have been inconsistent. This inconstancy could be because of the majority of studies evaluated salt intake at a single time point, which may be insufficient to accurately characterize salt intake throughout the observation period.MethodsIncluded were 77 605 participants from the Kailuan study. We assessed perceived salt intake via questionnaire in 2006, 2008, and 2010. Salt intake trajectories from 2006 to 2010 were identified using latent mixture models. Incident stroke cases were identified from 2010 to 2015 and confirmed by review of medical records. Cox proportional hazards model was used to examine the association between salt intake trajectories and stroke risk after adjusting for possible confounders, including age, sex, lifestyle, social economic status, body mass index, use of medicines, blood pressure, and lipoprotein profiles.ResultsIdentified were 5 distinct salt intake trajectories: moderate-stable (n=59 241), moderate-decreasing (n=9268), moderate-increasing (n=2975), low-increasing (n=2879), and high-decreasing (n=3242). During the 5-year follow-up period, there were 1564 incident strokes cases. Compared with individuals with the moderate-stable salt intake trajectory, individuals with moderate-decreasing salt intake trajectory had significantly lower cerebral infarction stroke risk (adjusted hazard ratio, 0.76; 95% confidence interval, 0.63-0.92) but not intracerebral hemorrhage risk (adjusted hazard ratio, 0.84; 95% confidence interval, 0.55-1.29). Further adjustment for 2006 or 2010 perceived salt intakes generated similar results. When baseline perceived salt intake only was used as the exposure, a significant dose-response relationship between higher perceived salt intake and higher stroke risk was observed (P trend=0.006).ConclusionsChange in salt intake was associated with the stroke risk. These data support the dietary recommendation to the reduction of salt intake.

Dataset Information

The potential impact of sleep-related movement disorders on stroke risk: a population-based longitudinal study.

Background

Aim

Design

Methods

Results

Conclusions

Publications

The potential impact of sleep-related movement disorders on stroke risk: a population-based longitudinal study.

Similar Datasets

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