Ontology highlight
ABSTRACT:
SUBMITTER: Webster L
PROVIDER: S-EPMC5914314 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Webster Lynn L Henningfield Jack J Buchhalter August R AR Siddhanti Suresh S Lu Lin L Odinecs Aleksandrs A Di Fonzo Carlo J CJ Eldon Michael A MA
Pain medicine (Malden, Mass.) 20180201 2
<h4>Objective</h4>Evaluate the human abuse potential, pharmacokinetics, pharmacodynamics, and safety of NKTR-181, a novel mu-opioid agonist molecule, relative to oxycodone.<h4>Design</h4>This randomized, single-center, double-blind, active- and placebo-controlled five-period crossover study enrolled healthy, adult, non-physically dependent recreational opioid users.<h4>Setting</h4>Inpatient clinical research site.<h4>Subjects</h4>Forty-two randomized subjects (73.8% male, 81% white, mean age = 2 ...[more]