Correlation of Pain Reduction with fMRI BOLD Response in Osteoarthritis Patients Treated with Paracetamol: Randomized, Double-Blind, Crossover Clinical Efficacy Study.
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ABSTRACT:
SUBMITTER: Yue Y
PROVIDER: S-EPMC5914370 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Publications
Correlation of Pain Reduction with fMRI BOLD Response in Osteoarthritis Patients Treated with Paracetamol: Randomized, Double-Blind, Crossover Clinical Efficacy Study.
Pain medicine (Malden, Mass.) 20180201 2
<h4>Objective</h4>To assess the relationship between the analgesic efficacy of extended-release paracetamol (ER-APAP) and brain blood oxygen level-dependent (BOLD) signal activation in response to painful stimulation measured by functional magnetic resonance imaging (fMRI) in patients with osteoarthritis of the knee.<h4>Methods</h4>This placebo-controlled, double-blind, crossover, randomized trial (N = 25) comprised three treatment periods in which patients received four doses of an eight-hour E ...[more]
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