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Concise Review: Human Pluripotent Stem Cells to Produce Cell-Based Cancer Immunotherapy.

ABSTRACT: Human pluripotent stem cells (PSCs) provide a promising resource to produce immune cells for adoptive cellular immunotherapy to better treat and potentially cure otherwise lethal cancers. Cytotoxic T cells and natural killer (NK) cells can now be routinely produced from human PSCs. These PSC-derived lymphocytes have phenotype and function similar to primary lymphocytes isolated from peripheral blood. PSC-derived T and NK cells have advantages compared with primary immune cells, as they can be precisely engineered to introduce improved anti-tumor activity and produced in essentially unlimited numbers. Stem Cells 2018;36:134-145.

SUBMITTER: Zhu H

PROVIDER: S-EPMC5914526 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature

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Concise Review: Human Pluripotent Stem Cells to Produce Cell-Based Cancer Immunotherapy.

Zhu Huang H Lai Yi-Shin YS Li Ye Y Blum Robert H RH Kaufman Dan S DS

Stem cells (Dayton, Ohio) 20180103 2

Human pluripotent stem cells (PSCs) provide a promising resource to produce immune cells for adoptive cellular immunotherapy to better treat and potentially cure otherwise lethal cancers. Cytotoxic T cells and natural killer (NK) cells can now be routinely produced from human PSCs. These PSC-derived lymphocytes have phenotype and function similar to primary lymphocytes isolated from peripheral blood. PSC-derived T and NK cells have advantages compared with primary immune cells, as they can be pr ...[more]

PMID: 29235195

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