Ontology highlight
ABSTRACT:
SUBMITTER: Wysoczynski-Horita CL
PROVIDER: S-EPMC5914528 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Wysoczynski-Horita Christina L CL Boursier Michelle E ME Hill Ryan R Hansen Kirk K Blackwell Helen E HE Churchill Mair E A MEA
Molecular microbiology 20180311 3
Pseudomonas aeruginosa is an opportunistic pathogen that uses the process of quorum sensing (QS) to coordinate the expression of many virulence genes. During quorum sensing, N-acyl-homoserine lactone (AHL) signaling molecules regulate the activity of three LuxR-type transcription factors, LasR, RhlR and QscR. To better understand P. aeruginosa QS signal reception, we examined the mechanism underlying the response of QscR to synthetic agonists and antagonists using biophysical and structural appr ...[more]