Ontology highlight
ABSTRACT:
SUBMITTER: Yang L
PROVIDER: S-EPMC5915020 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Yang Li L Han Bing B Zhang Yuan Y Bai Ying Y Chao Jie J Hu Gang G Yao Honghong H
Autophagy 20180129 3
Endothelial-mesenchymal transition (EndoMT) is associated with damage to blood-brain barrier (BBB) integrity. Circular RNAs (circRNAs) are highly expressed in the brain and are involved in brain diseases; however, whether circRNAs regulate the EndoMT in the brain remains unknown. Our study demonstrated that circHECW2 regulated the EndoMT by directly binding to MIR30D, a significantly downregulated miRNA from miRNA profiling, which subsequently caused an increased expression of ATG5. These findin ...[more]