Ontology highlight
ABSTRACT:
SUBMITTER: Vandeputte C
PROVIDER: S-EPMC5915153 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Vandeputte Caroline C Kehagias Pashalina P El Housni Hakim H Ameye Lieveke L Laes Jean-François JF Desmedt Christine C Sotiriou Christos C Deleporte Amélie A Puleo Francesco F Geboes Karen K Delaunoit Thierry T Demolin Gauthier G Peeters Marc M D'Hondt Lionel L Janssens Jos J Carrasco Javier J Marechal Raphaël R Galdon Maria Gomez MG Heimann Pierre P Paesmans Marianne M Flamen Patrick P Hendlisz Alain A
Oncotarget 20180403 25
Predictive biomarkers are eagerly awaited in advanced colorectal cancer (aCRC). Targeted sequencing performed on tumor and baseline plasma samples in 20 patients with aCRC treated with regorafenib identified 89 tumor-specific mutations of which ≥50% are also present in baseline plasma. Droplet digital PCR (ddPCR) assays were optimized to monitor circulating tumor DNA (ctDNA) levels in plasmatic samples collected throughout the treatment course and showed the importance of using the absolute valu ...[more]