Dataset Information

Prenatal Fluoride Exposure and Cognitive Outcomes in Children at 4 and 6-12 Years of Age in Mexico.

ABSTRACT:

Background

Some evidence suggests that fluoride may be neurotoxic to children. Few of the epidemiologic studies have been longitudinal, had individual measures of fluoride exposure, addressed the impact of prenatal exposures or involved more than 100 participants.

Objective

Our aim was to estimate the association of prenatal exposure to fluoride with offspring neurocognitive development.

Methods

We studied participants from the Early Life Exposures in Mexico to Environmental Toxicants (ELEMENT) project. An ion-selective electrode technique was used to measure fluoride in archived urine samples taken from mothers during pregnancy and from their children when 6-12 y old, adjusted for urinary creatinine and specific gravity, respectively. Child intelligence was measured by the General Cognitive Index (GCI) of the McCarthy Scales of Children's Abilities at age 4 and full scale intelligence quotient (IQ) from the Wechsler Abbreviated Scale of Intelligence (WASI) at age 6-12.

Results

We had complete data on 299 mother-child pairs, of whom 287 and 211 had data for the GCI and IQ analyses, respectively. Mean (SD) values for urinary fluoride in all of the mothers (n=299) and children with available urine samples (n=211) were 0.90?(0.35)?mg/L and 0.82?(0.38)?mg/L, respectively. In multivariate models we found that an increase in maternal urine fluoride of 0.5mg/L (approximately the IQR) predicted 3.15 (95% CI: -5.42, -0.87) and 2.50 (95% CI -4.12, -0.59) lower offspring GCI and IQ scores, respectively.

Conclusions

In this study, higher prenatal fluoride exposure, in the general range of exposures reported for other general population samples of pregnant women and nonpregnant adults, was associated with lower scores on tests of cognitive function in the offspring at age 4 and 6-12 y. https://doi.org/10.1289/EHP655.

SUBMITTER: Bashash M

PROVIDER: S-EPMC5915186 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature

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Publications

Prenatal Fluoride Exposure and Cognitive Outcomes in Children at 4 and 6-12 Years of Age in Mexico.

Bashash Morteza M Thomas Deena D Hu Howard H Martinez-Mier E Angeles EA Sanchez Brisa N BN Basu Niladri N Peterson Karen E KE Ettinger Adrienne S AS Wright Robert R Zhang Zhenzhen Z Liu Yun Y Schnaas Lourdes L Mercado-García Adriana A Téllez-Rojo Martha María MM Hernández-Avila Mauricio M

Environmental health perspectives 20170919 9

<h4>Background</h4>Some evidence suggests that fluoride may be neurotoxic to children. Few of the epidemiologic studies have been longitudinal, had individual measures of fluoride exposure, addressed the impact of prenatal exposures or involved more than 100 participants.<h4>Objective</h4>Our aim was to estimate the association of prenatal exposure to fluoride with offspring neurocognitive development.<h4>Methods</h4>We studied participants from the Early Life Exposures in Mexico to Environmenta ...[more]

PMID: 28937959

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Dataset Information

Prenatal Fluoride Exposure and Cognitive Outcomes in Children at 4 and 6-12 Years of Age in Mexico.

Background

Objective

Methods

Results

Conclusions

Publications

Prenatal Fluoride Exposure and Cognitive Outcomes in Children at 4 and 6-12 Years of Age in Mexico.

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