SNP and haplotype mapping for genetic analysis in the rat.
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ABSTRACT:
SUBMITTER: STAR Consortium
PROVIDER: S-EPMC5915293 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
Publications
SNP and haplotype mapping for genetic analysis in the rat.
Saar Kathrin K Beck Alfred A Bihoreau Marie-Thérèse MT Birney Ewan E Brocklebank Denise D Chen Yuan Y Cuppen Edwin E Demonchy Stephanie S Dopazo Joaquin J Flicek Paul P Foglio Mario M Fujiyama Asao A Gut Ivo G IG Gauguier Dominique D Guigo Roderic R Guryev Victor V Heinig Matthias M Hummel Oliver O Jahn Niels N Klages Sven S Kren Vladimir V Kube Michael M Kuhl Heiner H Kuramoto Takashi T Kuroki Yoko Y Lechner Doris D Lee Young-Ae YA Lopez-Bigas Nuria N Lathrop G Mark GM Mashimo Tomoji T Medina Ignacio I Mott Richard R Patone Giannino G Perrier-Cornet Jeanne-Antide JA Platzer Matthias M Pravenec Michal M Reinhardt Richard R Sakaki Yoshiyuki Y Schilhabel Markus M Schulz Herbert H Serikawa Tadao T Shikhagaie Medya M Tatsumoto Shouji S Taudien Stefan S Toyoda Atsushi A Voigt Birger B Zelenika Diana D Zimdahl Heike H Hubner Norbert N
Nature genetics 20080501 5
The laboratory rat is one of the most extensively studied model organisms. Inbred laboratory rat strains originated from limited Rattus norvegicus founder populations, and the inherited genetic variation provides an excellent resource for the correlation of genotype to phenotype. Here, we report a survey of genetic variation based on almost 3 million newly identified SNPs. We obtained accurate and complete genotypes for a subset of 20,238 SNPs across 167 distinct inbred rat strains, two rat reco ...[more]
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