Ontology highlight
ABSTRACT:
SUBMITTER: Kordaß T
PROVIDER: S-EPMC5915482 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Kordaß Theresa T Osen Wolfram W Eichmüller Stefan B SB
Frontiers in immunology 20180418
The NT5E (CD73) molecule represents an ecto-5'-nucleotidase expressed on the cell surface of various cell types. Hydrolyzing extracellular adenosine monophosphate into adenosine and inorganic phosphate, NT5E performs numerous homeostatic functions in healthy organs and tissues. Importantly, NT5E can act as inhibitory immune checkpoint molecule, since free adenosine generated by NT5E inhibits cellular immune responses, thereby promoting immune escape of tumor cells. MicroRNAs (miRNAs) are small n ...[more]