Antitumor effects of radionuclide treatment using ?-emitting meta-211At-astato-benzylguanidine in a PC12 pheochromocytoma model.

ABSTRACT: PURPOSE:Therapeutic options for patients with malignant pheochromocytoma are currently limited, and therefore new treatment approaches are being sought. Targeted radionuclide therapy provides tumor-specific systemic treatments. The ?-emitting radiopharmaceutical meta-131I-iodo-benzylguanidine (131I-MIBG) provides limited survival benefits and has adverse effects. A new generation of radionuclides for therapy using ?-particles including meta-211At-astato-benzylguanidine (211At-MABG) are expected to have strong therapeutic effects with minimal side effects. However, this possibility has not been evaluated in an animal model of pheochromocytoma. We aimed to evaluate the therapeutic effects of the ?-emitter 211At-MABG in a pheochromocytoma model. METHODS:We evaluated tumor volume-reducing effects of 211At-MABG using rat pheochromocytoma cell line PC12 tumor-bearing mice. PC12 tumor-bearing mice received intravenous injections of 211At-MABG (0.28, 0.56, 1.11, 1.85, 3.70 and 5.55 MBq; five mice per group). Tumor volumes were evaluated for 8 weeks after 211At-MABG administration. The control group of ten mice received phosphate-buffered saline. RESULTS:The 211At-MABG-treated mice showed significantly lower relative tumor growth during the first 38 days than the control mice. The relative tumor volumes on day 21 were 509.2%?±?169.1% in the control mice and 9.6%?±?5.5% in the mice receiving 0.56 MBq (p?

SUBMITTER: Ohshima Y 

PROVIDER: S-EPMC5915519 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature