Ontology highlight
ABSTRACT:
SUBMITTER: Li H
PROVIDER: S-EPMC5915573 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Li Huiping H Liu Jiang J Chen Jianing J Wang Huiyun H Yang Linbin L Chen Fei F Fan Siting S Wang Jing J Shao Bin B Yin Dong D Zeng Musheng M Li Mengfeng M Li Jun J Su Fengxi F Liu Qiang Q Yao Herui H Su Shicheng S Song Erwei E
Nature communications 20180424 1
Trastuzumab is a standard treatment for HER2-positive (HER2<sup>+</sup>) breast cancer, but some patients are refractory to the therapy. MicroRNAs (miRNAs) have been used to predict therapeutic effects for various cancers, but whether miRNAs can serve as biomarkers for HER2<sup>+</sup> metastatic breast cancer (MBC) patients remains unclear. Using miRNA microarray, we identify 13 differentially expressed miRNAs in the serum of HER2<sup>+</sup> MBC patients with distinct response to trastuzumab, ...[more]