Colonic motor response to wakening is blunted in slow transit constipation as detected by wireless motility capsule.

ABSTRACT: BACKGROUND:Chronic constipation may be categorized as normal transit (NTC), slow transit (STC), or outlet obstruction. Colonic wake response is a relative increase in colonic motility upon awakening. Colonic manometry studies have demonstrated attenuated wake response in STC. We sought to evaluate wake response among healthy (H), NTC, and STC patients using wireless motility capsule (WMC). METHODS:A retrospective study of WMC data from a multicenter clinical trial and a tertiary gastroenterology clinic was performed. WMC motility parameters of contraction frequency (Ct) and area under the contraction curve (AUC) were analyzed in 20-min windows 1-h before and after awakening. T-tests compared parameters between H, NTC, and STC. Linear regression analysis was performed to determine if outlet obstruction confounded data. A receiver operating characteristic curve demonstrated optimal Ct cut-offs to define blunted wake response. RESULTS:A total of 62?H, 53 NTC and 75 STC subjects were analyzed. At 20, 40, and 60?min after awakening, STC subjects had significantly lower mean Ct when compared to H (p?

SUBMITTER: Surjanhata B 

PROVIDER: S-EPMC5915586 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature