Ontology highlight
ABSTRACT:
SUBMITTER: Dhandapani R
PROVIDER: S-EPMC5915601 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Dhandapani Rahul R Arokiaraj Cynthia Mary CM Taberner Francisco J FJ Pacifico Paola P Raja Sruthi S Nocchi Linda L Portulano Carla C Franciosa Federica F Maffei Mariano M Hussain Ahmad Fawzi AF de Castro Reis Fernanda F Reymond Luc L Perlas Emerald E Garcovich Simone S Barth Stefan S Johnsson Kai K Lechner Stefan G SG Heppenstall Paul A PA
Nature communications 20180424 1
Mechanical allodynia is a major symptom of neuropathic pain whereby innocuous touch evokes severe pain. Here we identify a population of peripheral sensory neurons expressing TrkB that are both necessary and sufficient for producing pain from light touch after nerve injury in mice. Mice in which TrkB-Cre-expressing neurons are ablated are less sensitive to the lightest touch under basal conditions, and fail to develop mechanical allodynia in a model of neuropathic pain. Moreover, selective optog ...[more]