Ontology highlight
ABSTRACT:
SUBMITTER: Wilck N
PROVIDER: S-EPMC5916255 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Wilck Nicola N Markó Lajos L Balogh András A Kräker Kristin K Herse Florian F Bartolomaeus Hendrik H Szijártó István A IA Gollasch Maik M Reichhart Nadine N Strauss Olaf O Heuser Arnd A Brockschnieder Damian D Kretschmer Axel A Lesche Ralf R Sohler Florian F Stasch Johannes-Peter JP Sandner Peter P Luft Friedrich C FC Müller Dominik N DN Dechend Ralf R Haase Nadine N
JCI insight 20180222 4
Heart failure with preserved ejection fraction (HFpEF) can arise from cardiac and vascular remodeling processes following long-lasting hypertension. Efficacy of common HF therapeutics is unsatisfactory in HFpEF. Evidence suggests that stimulators of the nitric oxide-sensitive soluble guanylyl cyclase (NOsGC) could be of use here. We aimed to characterize the complex cardiovascular effects of NOsGC stimulation using NO-independent stimulator BAY 41-8543 in a double-transgenic rat (dTGR) model of ...[more]