Ontology highlight
ABSTRACT:
SUBMITTER: Rausch JC
PROVIDER: S-EPMC5916321 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Rausch John C JC Lavine Joel E JE Chalasani Naga N Guo Xiuqing X Kwon Soonil S Schwimmer Jeffrey B JB Molleston Jean P JP Loomba Rohit R Brunt Elizabeth M EM Chen Yii-Der Ida YI Goodarzi Mark O MO Taylor Kent D KD Yates Katherine P KP Rotter Jerome I JI
Journal of pediatric gastroenterology and nutrition 20180501 5
<h4>Background and objectives</h4>Nonalcoholic fatty liver disease (NAFLD) disproportionately affects Hispanic boys. Further, obesity and insulin resistance are major risk factors for NAFLD. No gene localization studies had been performed on children with biopsy-proven NAFLD. This study aims to identify genomic variants associated with increased adiposity and insulin resistance in a population of children with varying histologic severity of NAFLD.<h4>Methods</h4>We conducted a genome-wide associ ...[more]