Ontology highlight
ABSTRACT:
SUBMITTER: van Buuren N
PROVIDER: S-EPMC5916564 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
van Buuren Nicholas N Tellinghuisen Timothy L TL Richardson Christopher D CD Kirkegaard Karla K
eLife 20180328
Antiviral development is plagued by drug resistance and genetic barriers to resistance are needed. For HIV and hepatitis C virus (HCV), combination therapy has proved life-saving. The targets of direct-acting antivirals for HCV infection are NS3/4A protease, NS5A phosphoprotein and NS5B polymerase. Differential visualization of drug-resistant and -susceptible RNA genomes within cells revealed that resistant variants of NS3/4A protease and NS5A phosphoprotein are <i>cis</i>-dominant, ensuring the ...[more]