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Chilean Gastric Cancer Task Force: A study protocol to obtain a clinical and molecular classification of a cohort of gastric cancer patients.


ABSTRACT: Gastric cancer (GC) is the world's second-leading cause of neoplastic mortality. Genetic alterations, response to treatments, and mortality rates are highly heterogeneous across different regions. Within Latin America, GC is the leading cause of cancer death in Chile, affecting 17.6 per 100,000 people and causing >3000?deaths/y. Clinical outcomes and response to "one size fits all" therapies are highly heterogeneous and thus a better stratification of patients may aid cancer treatment and response.The Gastric Cancer Task Force is a Chilean collaborative, noninterventional study that seeks to stratify gastric adenocarcinomas using clinical outcomes and genomic, epigenomic, and protein alterations in a cohort of 200 patients. Tumor samples from the Pathology Department and the Cancer Center at UC-Christus healthcare network, Pontificia Universidad Católica de Chile will be analyzed using a panel of 143 known cancer genes (Oncomine Comprehensive Assay) at the Center of Excellence in Precision Medicine in Santiago, Chile. In addition, promoter methylation for selected genes will be performed along with tissue microarray for clinically relevant proteins (e.g., PD-L1, Erb-2, VEGFR2, among others) and Helicobacter pylori and Epstein-Barr virus status. Obtained data will be correlated to 120 clinical parameters retrieve from medical records, including general patient information, cancer history, laboratory studies, comorbidity index, chemotherapy, targeted therapies, efficacy, and follow-up.The development of a clinically meaningful classification that encompasses comprehensive clinical and molecular parameters may improve patient treatment, predict clinical outcomes, aid patient selection/stratification for clinical trials and may offer insights into future preventive and/or therapeutic strategies in patients from Latin America region. TRIAL REGISTRATION:ClinicalTrials.gov Identifier: NCT03158571, Registered on May 18, 2017.

SUBMITTER: Owen GI 

PROVIDER: S-EPMC5916646 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature

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Chilean Gastric Cancer Task Force: A study protocol to obtain a clinical and molecular classification of a cohort of gastric cancer patients.

Owen Gareth I GI   Pinto Mauricio P MP   Retamal Ignacio N IN   Fernádez María F MF   Cisternas Betzabe B   Mondaca Sebastian S   Sanchez Cesar C   Galindo Hector H   Nervi Bruno B   Ibañez Carolina C   Acevedo Francisco F   Madrid Jorge J   Peña José J   Bravo Maria Loreto ML   Maturana Maria Jose MJ   Cordova-Delgado Miguel M   Romero Diego D   de la Jara Nathaly N   Torres Javiera J   Rodriguez-Fernandez Maria M   Espinoza Manuel M   Balmaceda Carlos C   Freire Matías M   Gárate-Calderón Valentina V   Crovari Fernando F   Jimenez-Fonseca Paula P   Carmona-Bayonas Alberto A   Zwenger Ariel A   Armisen Ricardo R   Corvalan Alejandro H AH   Garrido Marcelo M  

Medicine 20180401 16


Gastric cancer (GC) is the world's second-leading cause of neoplastic mortality. Genetic alterations, response to treatments, and mortality rates are highly heterogeneous across different regions. Within Latin America, GC is the leading cause of cancer death in Chile, affecting 17.6 per 100,000 people and causing >3000 deaths/y. Clinical outcomes and response to "one size fits all" therapies are highly heterogeneous and thus a better stratification of patients may aid cancer treatment and respon  ...[more]

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