Ontology highlight
ABSTRACT:
SUBMITTER: Le Marchand T
PROVIDER: S-EPMC5916882 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Nature communications 20180425 1
Spontaneous aggregation of folded and soluble native proteins in vivo is still a poorly understood process. A prototypic example is the D76N mutant of beta-2 microglobulin (β2m) that displays an aggressive aggregation propensity. Here we investigate the dynamics of β2m by X-ray crystallography, solid-state NMR, and molecular dynamics simulations to unveil the effects of the D76N mutation. Taken together, our data highlight the presence of minor disordered substates in crystalline β2m. The destab ...[more]