Ontology highlight
ABSTRACT:
SUBMITTER: Vujic A
PROVIDER: S-EPMC5916892 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Vujic Ana A Lerchenmüller Carolin C Wu Ting-Di TD Guillermier Christelle C Rabolli Charles P CP Gonzalez Emilia E Senyo Samuel E SE Liu Xiaojun X Guerquin-Kern Jean-Luc JL Steinhauser Matthew L ML Lee Richard T RT Rosenzweig Anthony A
Nature communications 20180425 1
Loss of cardiomyocytes is a major cause of heart failure, and while the adult heart has a limited capacity for cardiomyogenesis, little is known about what regulates this ability or whether it can be effectively harnessed. Here we show that 8 weeks of running exercise increase birth of new cardiomyocytes in adult mice (~4.6-fold). New cardiomyocytes are identified based on incorporation of <sup>15</sup>N-thymidine by multi-isotope imaging mass spectrometry (MIMS) and on being mononucleate/diploi ...[more]