An Assay that Predicts In Vivo Efficacy for DNA Aptamers that Stimulate Remyelination in a Mouse Model of Multiple Sclerosis.
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ABSTRACT:
SUBMITTER: Heider RM
PROVIDER: S-EPMC5918178 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Publications
An Assay that Predicts <i>In Vivo</i> Efficacy for DNA Aptamers that Stimulate Remyelination in a Mouse Model of Multiple Sclerosis.
Heider Robin M RM Smestad John A JA Lemus Hernan Nicolas HN Wilbanks Brandon B Warrington Arthur E AE Peters Justin P JP Rodriguez Moses M Maher L James LJ
Molecular therapy. Methods & clinical development 20180321
Multiple sclerosis (MS) is a debilitating disease for which regenerative therapies are sought. We have previously described human antibodies and DNA aptamer-streptavidin conjugates that promote remyelination after systemic injection into mice infected by Theiler's murine encephalomyelitis virus. Here, we report an <i>in vitro</i> assay of myelin binding with results that correlate with remyelination outcome <i>in vivo</i>, as shown for data from a set of DNA aptamer complexes of different size a ...[more]
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