Ontology highlight
ABSTRACT:
SUBMITTER: Muller C
PROVIDER: S-EPMC5918243 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Müller Claudia C Charniga Carol C Temple Sally S Finnemann Silvia C SC
Stem cell reports 20180215 3
With stem cell-derived retinal pigment epithelial (RPE) replacement therapies in clinical testing, establishing potency of RPE prior to transplantation is imperative. Phagocytosis of photoreceptor outer segment fragments (POS) is a key indicator of RPE functionality. Comparing RPE derived from different donor human adult RPE stem cell lines, we found that cells were either high-phagocytic or low-phagocytic despite sharing phagocytic receptors and ligands, junctional ZO-1, and lack of epithelial- ...[more]